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  4. Risk of COPD Exacerbations Associated with Statins versus Fibrates: A New User, Active Comparison, and High-Dimensional Propensity Score Matched Cohort Study
 
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Risk of COPD Exacerbations Associated with Statins versus Fibrates: A New User, Active Comparison, and High-Dimensional Propensity Score Matched Cohort Study

Journal
International journal of chronic obstructive pulmonary disease
Journal Volume
16
Date Issued
2021
Author(s)
Sun, Shu-Hui
CHIA-HSUIN CHANG  
Zhan, Zhe-Wei
Chang, Wen-Hsuan
Chen, Yu-An
Dong, Yaa-Hui
DOI
10.2147/COPD.S323391
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/589731
URL
https://api.elsevier.com/content/abstract/scopus_id/85117257173
Abstract
Several observational studies have found that statins may materially decrease the risk of chronic obstructive pulmonary disease (COPD) exacerbations. However, most of these studies used a prevalent user, non-user comparison approach, which may lead to overestimation of the clinical benefits of statins. We aimed to explore the risk of COPD exacerbations associated with statins with a new user, active comparison approach to address potential methodological concerns. We selected fibrates, another class of lipid-lowering agents, as the reference group because no evidence suggests that fibrates have an effect on COPD exacerbations.
Subjects
active comparison; acute exacerbations; chronic obstructive pulmonary disease; cohort study; high-dimensional propensity score; new users; statins
Active comparison; Acute exacerbations; Chronic obstructive pulmonary disease; Cohort study; High-dimensional propensity score; New users; Statins
SDGs

[SDGs]SDG3

Other Subjects
fibric acid derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; chronic obstructive lung disease; cohort analysis; disease exacerbation; human; propensity score; Cohort Studies; Disease Progression; Fibric Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Propensity Score; Pulmonary Disease, Chronic Obstructive
Type
journal article

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