Lifetime risk of distinct upper aerodigestive tract cancers and consumption of alcohol, betel and cigarette
Journal
International Journal of Cancer
Journal Volume
135
Journal Issue
6
Pages
1480-1486
Date Issued
2014
Author(s)
Hsu W.-L.
Chien Y.-C.
Yang H.-I.
Yu K.J.
You S.-L.
Wang L.-Y.
Chen S.-Y.
Yang C.-S.
Chen C.-J.
Abstract
The cancer of upper aerodigestive tract (UADT) is a common cancers in the world. However, its lifetime risk by consumption of alcohol, betel and cigarettes remain to be elucidated. This study aimed to estimate lifetime risk of distinct UADT cancers and assess their associations with alcohol, betel and cigarette consumption. Three cohorts of 25,611 men were enrolled in 1982-1992 in Taiwan. The history of alcohol, betel and cigarette consumption was enquired through questionnaire interview. Newly developed UADT cancers were ascertained through computerized linkage with national cancer registry profile. Lifetime (30-80 years old) risk and multivariate-adjusted hazard ratio (HRadj) of distinct UADT cancers by alcohol, betel and cigarette consumption were estimated. A total of 269 pathologically confirmed cases of UADT cancers were newly-diagnosed during 472,096 person-years of follow-up. The lifetime risk of UADT cancer was 9.42 and 1.65% for betel chewers and nonchewers, 3.22 and 1.21% for cigarette smokers and nonsmokers and 4.77 and 1.85% for alcohol drinkers and nondrinkers. The HRadj (95% confidence interval) of developing UADT cancer was 3.36 (2.51-4.49), 2.02 (1.43-2.84), 1.90 (1.46-2.49), respectively, for the consumption of betel, cigarette and alcohol. Alcohol, betel and cigarette had different effect on cancers at various anatomical sites of UADT. The cancer risk from the mouth, pharynx, esophagus to larynx increased for alcohol and cigarette consumption, but decreased for betel consumption. Alcohol, betel and cigarette consumption are independent risk predictors for distinct UADT cancers. What's new? Betel quid chewing, alcohol consumption, and cigarette smoking are associated with an increased risk of upper aerodigestive tract (UADT) cancers, though lifetime risk associations have not been fully elucidated. The present study estimated lifetime risk of distinct UADT cancers in three male cohorts in Taiwan over a twenty-year period. The findings show that for alcohol and cigarette consumption the risk of cancer was higher at sites in the throat compared to the mouth, while an opposite pattern was observed for betel quid chewing. Cumulative UADT risk reached 17.2% for men who chewed more than 20 betel quids per day. ? 2014 UICC.
SDGs
Other Subjects
alcohol; adult; alcohol consumption; article; betel nut; cancer incidence; cancer risk; chewing gum; cohort analysis; community assessment; controlled study; digestive system cancer; disease association; female; follow up; food intake; human; major clinical study; male; medical history; middle aged; outcome assessment; priority journal; prospective study; risk assessment; risk factor; sex difference; smoking; Taiwan; upper aerodigestive system cancer; alcohol drinking; betel quid chewing; cigarette smoking; cumulative lifetime incidence; UADT cancers; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Areca; Cohort Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Smoking; Taiwan
Publisher
Wiley-Liss Inc.
Type
journal article