Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi
Journal
Marine Drugs
Journal Volume
9
Journal Issue
10
Pages
2036-2045
Date Issued
2011
Author(s)
Abstract
Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. ? 2011 by the authors; licensee MDPI.
Subjects
Anti-inflammatory activity; Cladiella krempfi; Cytotoxic activity; Eunicellin-based diterpenoids; Krempfielins; Soft coral
Other Subjects
cyclooxygenase 2; diterpenoid; krempfielin A; krempfielin B; krempfielin C; krempfielin D; lipopolysaccharide; nitric oxide synthase; unclassified drug; antiinflammatory activity; article; cancer cell culture; carbon nuclear magnetic resonance; Cladiella krempfi; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; drug synthesis; human; human cell; in vitro study; macrophage; nonhuman; nuclear Overhauser effect; spectroscopy; Alcyonacea; Cladiella
Type
journal article