Tomographic Reconstruction of Biological Cell Structures Using Optical Coherence Tomography Measurements Via Finite-Difference Time-Domain Simulations
Date Issued
2014
Date
2014
Author(s)
Wang, Shiang-Jiu
Abstract
ABSTRACT
Optical Coherence Tomography (OCT) imaging can be performed by processing the raw data, the information such as refractive indices contained in the carrier raw data is completely neglected. The goal of this thesis is to analyze the carrier raw data generated by OCT via Finite-Difference Time-Domain method (FDTD) and to reconstruct the refractive indices from the carrier raw data. OCT imaging is performed by Michelson interferometer. Light reflected from sample arm coupling with light reflected from reference arm forms interferometry and then is detected by charge-coupled device (CCD), which is how the OCT performs imaging. The mechanism of the reflection of light follows the Fresnel’s equation. The simulation results indicate that when the sample is homogeneous and simple structure, the interferometry shows up at the boundary of the sample, while the finer structures show reflections but hard to specify the exact boundary. The cell model, tissue model, and epidermis tissue model are shown respectively in our simulation. The relative error of the calculated refractive indices is mainly from the fine structures. It is shown how the fine structure of the sample would affect the reflected signals and reconstruction. Results show that the noise signals would blur the OCT images, which also affect the calculation of refractive indices.
Subjects
光學同調掃描術
麥克森干涉儀
時域有限差分法
菲涅耳方程式
折射率
Type
thesis
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