Functional impairment of dendritic cells in patients infected with hepatitis C virus genotype 1 who failed peginterferon plus ribavirin therapy
Journal
Journal of Medical Virology
Journal Volume
83
Journal Issue
7
Pages
1212-1220
Date Issued
2011
Author(s)
Abstract
Although chronic hepatitis C patients have a lower frequency and functions of dendritic cells (DCs) than healthy subjects, little is known about the serial changes in frequency and functions of DCs following anti-viral treatment and the relationship with treatment outcomes. Twenty patients with hepatitis C virus genotype 1 receiving peginterferon (PEG-IFN) and ribavirin for 24 weeks were enrolled. The frequency and functions of DCs were assayed at baseline and 24 weeks post-treatment. Ten sex and age-matched healthy adults served as controls. Nineteen of the 20 chronic hepatitis C patients completed 24 weeks of combination therapy. Fifteen patients achieved rapid virologic response and 12 achieved sustained virologic response (SVR). The baseline frequency of peripheral blood myeloid DCs and plasmacytoid DCs was significantly lower in chronic hepatitis C patients than in healthy controls. In patients who achieved SVR, the frequency of DCs subsets at the end of follow-up increased to a level comparable to healthy controls. Although no functional defects of DCs was found in chronic hepatitis C patients in comparison with healthy controls, in patients without SVR had a lower CD83 expression and higher interleukin-10 production of DCs than SVR patients. The results suggest that low CD83 expression and high IL-10 production of DCs at the baseline may predict a poor virologic response to 24-week PEG-IFN plus ribavirin therapy in HCV genotype 1 patients. ? 2011 Wiley-Liss, Inc.
SDGs
Other Subjects
B7 antigen; CD83 antigen; CD86 antigen; gamma interferon; HLA DR antigen; interleukin 10; interleukin 12p40; interleukin 12p70; peginterferon alpha2b; ribavirin; virus RNA; adult; antigen expression; article; cell function; clinical article; controlled study; cytokine production; dendritic cell; disease severity; drug treatment failure; female; follow up; functional disease; genotype; hepatitis C; Hepatitis C virus; human; human tissue; liver biopsy; liver fibrosis; male; myeloid dendritic cell; nonhuman; phenotype; plasmacytoid dendritic cell; treatment duration; treatment response; virus load; Adult; Antigens, CD; Antiviral Agents; Biological Markers; Case-Control Studies; China; Dendritic Cells; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepacivirus; Hepatitis C, Chronic; Humans; Immunoglobulins; Interferon Alfa-2b; Interleukin-10; Male; Membrane Glycoproteins; Middle Aged; Polyethylene Glycols; Predictive Value of Tests; Ribavirin; RNA, Viral; Treatment Outcome; Hepatitis C virus; Hepatitis C virus genotype 1
Type
journal article