Relationship of mucopolysaccharide change, Helicobacter pylori infection and expression of P-53 in gastric cancer
Journal
Tzu Chi Medical Journal
Journal Volume
9
Journal Issue
1
Pages
27-33
Date Issued
1997
Author(s)
Abstract
Gastric cancer (GC) still occupies a leading cause of cancer death. How to find an early detection index and prognostic factors are mandatory in cancer prevention. We have analyzed 112 gastrectomized specimens operated during 1992 to 1994 and classified them into subtypes (diffuse or intestinal) by Lauren's classification. From these specimens, we tried to find the correlation among change of mucopolysaccharide, status of Helicobacter pylori and overexpression of P-53 protein. We used high iron diamine to differentiate the mucin character and immunohistochemical stains to detect overexpression of P-53 protein. The results reveal positive P-53 staining in 61 (54.5%) of 112 specimens. However, P-53 expression was not associated with age, sex, lymph node metastasis, H. pylori infection or prognosis. Instead there was higher frequency of P-53 staining in advanced (60.7%), intestinal (69.8%) and cardiac (76.5%) cancer. The coexistence of GC and type III intestinal metaplasia is increased in frequency (42.9%), especially the intestinal type (66.7%, 42/63 vs 12.2%, 6/49; x2 p value < 0.01). Thus we conclude that appearance of type III intestinal metaplasia may represent as a risk factor in intestinal type cancer just as atrophic gastritis to the GC. Overexpression of P-53 protein seems to indicate a different pathway in carcinogenesis while the exact pathway still needs to be elucidated. As for the role of H. pylori, examinations on more specimens are needed to determine.
SDGs
Other Subjects
glycosaminoglycan; protein p53; adult; aged; article; carcinogenesis; female; gene expression regulation; helicobacter pylori; human; human tissue; immunoreactivity; major clinical study; male; risk factor; stomach cancer
Type
journal article