Antiplatelet and vasorelaxing actions of some benzylisoquinoline and phenanthrene alkaloids
Journal
Journal of Natural Products
Journal Volume
59
Journal Issue
5
Pages
531-534
Date Issued
1996
Author(s)
CHE-MING TENG
Abstract
Members of a series of benzylisoquinoline and phenanthrene alkaloids were tested for their antiplatelet and vasorelaxing actions. Atherosperminine HClO4 (15) and atherosperminium I (16) showed strong inhibition of adenosine 5'-diphosphate-induced platelet aggregation. dl-N- Methylcoclaurine (1), dl-coclaurine (6), 15, 16, xylopine hydroxylamine (18), and atherosperminine N-oxide (19) showed strong inhibition of arachidonic acid-induced platelet aggregation. Compounds 1, 15, 16, dicentrine methine (17), 18, and 19 showed strong inhibition of collagen- induced platelet aggregation. d-(-)-Magnocurarine I (8), 15, and 16 showed strong inhibition of platelet-activating factor-induced platelet aggregation. Compounds 15, 17, and 19 showed vasorelaxing action in rat thoracic aorta.
SDGs
Other Subjects
armepavine; benzylisoquinoline derivative; coclaurine; dicentrine; glaucine; laudanosine; phenanthrene derivative; reticuline; xylopine; animal cell; arachidonic acid metabolism; article; atherosclerosis; blood clot lysis; cardiovascular disease; drug effect; nonhuman; rabbit; thrombocyte aggregation; thrombosis; vascular smooth muscle; vasodilatation; Alkaloids; Animals; Aorta, Thoracic; Female; Muscle Relaxation; Muscle, Smooth, Vascular; Platelet Aggregation Inhibitors; Rabbits; Rats; Vasodilator Agents; Animalia; Oryctolagus cuniculus
Type
journal article