Microfluidic Device with Dual Mechanical Cues for Cell Migration Investigation
Date Issued
2012
Date
2012
Author(s)
Tsai, Chin-Hsiung
Abstract
Cell migration plays an important role in both physiology and disease, such as angiogenesis, wound healing and cancer metastasis. Therefore, understanding the fundamental mechanisms of cell migration is crucial to create strategies for disease treatment and regenerative medicine. Some biomechanical cues have been well studied about their effects on guiding cell migration, however, few discuss about simultaneously generating dual or multiple cues to affect cell migration. Here, we integrated a gradient-compliant polyacrylamide (PA) gel into the microfluidic system, thus enabling the device to provide dual mechanical cues at the same time. By adopting this advanced device, we can investigate the effects of stiffness and osmotic gradients on guiding cell migration in a more in vivo-like environment, and this dual cues system might also be useful for other applications.
Subjects
cell migration
microfluidics
hydrogel
stiffness gradient
osmotic gradient
SDGs
Type
thesis
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