Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan
Journal
Schizophrenia Bulletin
Journal Volume
28
Journal Issue
3
Pages
379-392
Date Issued
2002
Author(s)
Chang C.-J.
Liu S.K.
Cheng J.J.
Yang W.-C.O.
Chang H.-J.
Lane H.-Y.
Lin S.-K.
Yang T.-W.
Abstract
This study aimed to assess the boundaries of the schizophrenia spectrum and whether inclusion of such phenotypes increases power for linkage analysis of schizophrenia. Participants were 234 first degree relatives (FDRs) of 94 schizophrenia probands in Northern Taiwan who completed a direct interview using the Diagnostic Interview for Genetic Studies (DIGS). Based on best estimate diagnosis, the morbidity risk in the relatives for schizophrenia was 2.5 percent (Weinberg's shorter method) or 3.9 percent (Kaplan-Meier estimate). Depending on the stringency of diagnosis, lifetime prevalence was 2.6 percent to 4.7 percent for schizotypal personality disorder, 3.4 percent to 8.6 percent for paranoid personality disorder, and 1.3 percent to 3.4 percent for schizoid personality disorder. These figures are significantly higher than the corresponding figures in the general population. However, none of the recurrence risk ratio for any spectrum that included both schizophrenia and a personality disorder (3.0 to 5.9) was greater than that of schizophrenia alone (9.3 to 14.4). Thus, including schizophreniarelated personality disorders in the spectrum did not increase power for linkage analysis of schizophrenia.
SDGs
Publisher
DHHS Public Health Service
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
41.pdf
Size
1.32 MB
Format
Adobe PDF
Checksum
(MD5):c641e15caf8b61a24a20d64e46d63a64