MicroRNA-125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications
Journal
Journal of Cellular and Molecular Medicine
Journal Volume
23
Journal Issue
9
Pages
5884-5894
Date Issued
2019
Author(s)
Abstract
Epigenetic changes, particularly non-coding RNAs, have been implicated extensively in the pathogenesis of vascular diseases. Specific miRNAs are involved in the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition of endothelial cells and/or vascular smooth muscle cells. MicroRNA-125b has been studied in depth for its role in carcinogenesis with a double-edged role; that is, it can act as an oncogene in some cancer types and as a tumour suppressor gene in others. However, cumulative evidence from the use of advanced miRNA profiling techniques and bioinformatics analysis suggests that miR-125b can be a potential mediator and useful marker of vascular diseases. Currently, the exact role of miR-125b in vascular diseases is not known. In this systematic review, we intend to provide an updated compilation of all the recent findings of miR-125b in vascular diseases, using a systematic approach of retrieving data from all available reports followed by data summarization. MiR-125b serves as a pathogenic player in multiple vascular pathologies involving endothelia and vascular smooth muscle cells and also serves as a diagnostic marker for vascular diseases. We further provide a computational biologic presentation of the complex network of miR-125b and its target genes within the scope of vascular diseases. ? 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.
SDGs
Other Subjects
CD40 antigen; endothelin 1; intercellular adhesion molecule 1; interleukin 6; microRNA 125b; osteocalcin; osteoprotegerin; oxidized low density lipoprotein; podocalyxin; protein Bak; protein p53; transcription factor RUNX2; tumor necrosis factor; vascular endothelial cadherin; biological marker; microRNA; MIRN125 microRNA, human; abdominal aortic aneurysm; acute coronary syndrome; apoptosis; atherogenesis; atheroma; atherosclerosis; bioinformatics; blood vessel calcification; carcinogenesis; cell proliferation; chronic kidney failure; coronary artery ligation; cytokine production; DNA methylation; DNA microarray; epigenetics; gene control; gene expression; gene overexpression; gene sequence; glioma; head and neck cancer; heart failure; human; inflammation; liver injury; loss of function mutation; melanoma; non small cell lung cancer; pathogenesis; phenotype; Pi3K/Akt signaling; priority journal; Review; risk factor; single nucleotide polymorphism; systematic review; upregulation; vascular disease; vascular smooth muscle cell; cytology; endothelium cell; genetic epigenesis; genetics; pathology; vascular disease; vascular smooth muscle; Biomarkers; Endothelial Cells; Epigenesis, Genetic; Humans; MicroRNAs; Muscle, Smooth, Vascular; Vascular Calcification; Vascular Diseases
Publisher
Blackwell Publishing Inc.
Type
review