Extraction of radiomic values from lung adenocarcinoma with near-pure subtypes in the International Association for the Study of Lung Cancer/the American Thoracic Society/the European Respiratory Society (IASLC/ATS/ERS) classification
Journal
Lung Cancer
Journal Volume
119
Pages
56-63
Date Issued
2018
Author(s)
Chen, L.-W.
Wang, H.-J.
Chen, L.-R.
Lor, K.-L.
Chen, Y.-C.
Abstract
Introduction: Histological subtypes of lung adenocarcinomas (ADCs) classified by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) system have been investigated using radiomic approaches. However, the results have had limitations since <80% of invasive lung ADCs were heterogeneous, with two or more subtypes. To reduce the influence of heterogeneity during radiomic analysis, computed tomography (CT) images of lung ADCs with near-pure ADC subtypes were analyzed to extract representative radiomic features of different subtypes. Methods: We enrolled 95 patients who underwent complete resection for lung ADC and a pathological diagnosis of a “near-pure” (?70%) IASLC/ATS/ERS histological subtype. Conventional histogram/morphological features and complex radiomic features (grey-level-based statistical features and component variance-based features) of thin-cut CT data of tumor regions were analyzed. A prediction model based on leave-one-out cross-validation (LOOCV) and logistic regression (LR) was used to classify all five subtypes and three pathologic grades (lepidic, acinar/papillary, micropapillary/solid) of ADCs. The validation was performed using 36 near-pure ADCs in a later cohort. Results: A total of 31 lepidic, 14 papillary, 32 acinar, 10 micropapillary, and 8 solid ADCs were analyzed. With 21 conventional and complex radiomic features, for 5 subtypes and 3 pathological grades, the prediction models achieved accuracy rates of 84.2% (80/95) and 91.6% (87/95), respectively, while accuracy was 71.6% and 85.3%, respectively, if only conventional features were used. The accuracy rate for the validation set (n = 36) was 83.3% (30/36) and 94.4% (34/36) in 5 subtypes and 3 pathological grades, respectively, using conventional and complex features, while it was 66.7% and 77.8% only using conventional features, respectively. Conclusion: Lung ADC with high purity pathological subtypes demonstrates strong stratification of radiomic values, which provide basic information for accurate pathological subtyping and image parcellation of tumor sub-regions. ? 2018 Elsevier B.V.
SDGs
Other Subjects
accuracy; Article; cancer classification; cancer patient; cancer staging; cancer surgery; cohort analysis; computer assisted tomography; histogram; histology; human; human tissue; image analysis; lung adenocarcinoma; major clinical study; pathology; prediction; priority journal; radiological parameters; diagnostic imaging; Europe; lung; lung adenocarcinoma; lung resection; lung tumor; medical society; mortality; pathology; retrospective study; survival analysis; United States; x-ray computed tomography; Adenocarcinoma of Lung; Cohort Studies; Europe; Humans; Lung; Lung Neoplasms; Neoplasm Staging; Pneumonectomy; Retrospective Studies; Societies, Medical; Survival Analysis; Tomography, X-Ray Computed; United States
Publisher
Elsevier Ireland Ltd
Type
journal article