Rodent Model for Long-Term Maintenance and Development of the Viable Cysticerci of Taenia Saginata Asiatica
Resource
THE KOREAN JOURNAL OF PARASITOLOGY v.38 n.4 pp.237-244
Journal
THE KOREAN JOURNAL OF PARASITOLOGY
Journal Volume
v.38
Journal Issue
n.4
Pages
237-244
Date Issued
2000
Date
2000
Author(s)
WANG, I.-C.
CHUNG, WEN-CHENG
LU, SEN- CHI
FAN, P-C
Abstract
Although oncospheres of Taenia saginata asiatica can develop into cysticerci in immunodeficiency, immunosuppressed and normal mice, no detailed information on the development features of these cysticerci from SCID mice is available. In the present study, the tumor-like cyst was found in the subcutaneous tissues of each of 10 SCID mice after 38-244 days inoculation with 39,000 oncospheres of T. s. asiatica. These cysts weighed 2.0-9.6 gm and were 1.5-4.3 cm in diameter. The number of ctsticerci were collected from these cysts ranged from 125 to 1794 and the cysticerci recovery rate from 0.3% to 4.6%. All cysticerci were viable with a diameter of 1-6 mm and 9 abnormal ones each with 2 evaginated protoscoleces were also found. The mean length and width of scolex, protoscolex, and bladder were 477x558, 756x727 and 1586x1615 um, respectively. The diameters of suckers and rostellum were 220 um and 70 um , respectively. All cysticerci had two rows of rostellar hooks. These findings suggest that the SCID mouse model can employed as a tool for long -term maintenance of the biological materials for advanced studies of immunodiagnosis, vaccine development , and evaluation of cestocidal drugs which would be most benefit for the good health of the livestocks.
Subjects
cesticerci
SCID mice
Taenia saginata asiatica
SDGs