Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in HIV-infected individuals in Taiwan
Journal
Clinical Infectious Diseases
Journal Volume
48
Journal Issue
6
Pages
832-835
Date Issued
2009
Author(s)
Ko W.-S.
Chang L.-Y.
Chen M.-Y.
Chang S.-F.
Liu W.-C.
Wu C.-H.
Hsu H.-J.
Lee C.-N.
Abstract
We investigated the relationship between hypertriglyceridemia and the single-nudeotide polymorphisms(SNPs) on APOA5 in human immunodeficiency virus(HlV)-infected patients receiving highly active antiretroviral therapy(HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP117 SNP2G/SNP3C/C.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia(triglyceride level, >500 mg/dL).?2009 by the Infectious Diseases Society of America. All rights reserved.
SDGs
Other Subjects
antilipemic agent; atazanavir; efavirenz; indinavir; indinavir plus ritonavir; lopinavir plus ritonavir; nelfinavir; nevirapine; proteinase inhibitor; ritonavir; ritonavir plus saquinavir; RNA directed DNA polymerase inhibitor; saquinavir; stavudine; triacylglycerol; APOA5 protein, human; apolipoprotein A; adult; aged; APOA5 gene; article; controlled study; female; gene; genetic association; genetic variability; haplotype; highly active antiretroviral therapy; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; major clinical study; male; priority journal; side effect; single nucleotide polymorphism; Taiwan; triacylglycerol blood level; genetics; highly active antiretroviral therapy; Human immunodeficiency virus infection; hypertriglyceridemia; middle aged; point mutation; Adult; Aged; Aged, 80 and over; Antiretroviral Therapy, Highly Active; Apolipoproteins A; Female; Haplotypes; HIV Infections; HIV Protease Inhibitors; Humans; Hypertriglyceridemia; Male; Middle Aged; Point Mutation; Polymorphism, Single Nucleotide; Taiwan; Young Adult
Type
journal article