ANDROGEN RECEPTOR EXON 1 CAG REPEAT LENGTH AND RISK OF HEPATOCELLULAR CARCINOMA IN WOMEN
Resource
HEPATOLOGY v.36 n.1 pp.156-163
Journal
HEPATOLOGY
Journal Volume
v.36
Journal Issue
n.1
Pages
156-163
Date Issued
2002
Date
2002
Author(s)
YU, MING-WHEI
Abstract
The androgen receptor (AR) gene is localized on chromosome X , and shorter CAG repeats in exon 1 of the AR gene were recently suggested to increase hepatitis B virus (HBV)- related hepatocellular carcinoma (HCC) risk among men. To examine whether the relationship between the AR-CAG repeats and HCC was also evident among women, we conducted a case- control study in Taiwan. The number of AR-CAG repeats was determined for 238 women with HCC and 354 unrelated control subjects (comprising 188 first-degree and 166 nonbiological relatives) selected from female relatives of patients with HCC. Women harboring 2 AR alleles with more than 23 CAG repeats had an increased risk of HCC (age-adjusted odds ratio [OR], 1.82; 95% CI, 1.06-3.14), compared with women with only short alleles or a single long allele. The association between harboring 2 AR alleles containing longer CAG repeats and HCC was more striking among HBV carriers ( age-adjusted OR for more than 22 repeats, 2.23; 95% CI, 1.14 -4.34) and particularly prominent among HBV carriers under age 53 years (age-adjusted OR, 3.16; 95% CI, 1.13-8.82). When CAG repeats were analyzed as a continuous variable, the increase in HCC risk associated with each incremental repeat in the shorter of 2 alleles in a given genotype was statistically significant among women with a first-degree relative with HCC (age-adjusted OR, 1.18; 95% CI, 1.01-1.37) . No such relationship was detected among women without the family history. In conclusion, our observations suggest that the AR-CAG alleles may contribute to HCC predisposition among women through a mechanism different from that for men .
Subjects
HEPATITIS-B CARRIERS
PROSTATE-CANCER CELLS
S-TRANSFERASE M1
BREAST-CANCER
TRANSGENIC MICE
GENETIC SUSCEPTIBILITY
SDGs
Type
journal article