Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation
Journal
Stem cell research & therapy
Journal Volume
13
Journal Issue
1
Date Issued
2022-11-12
Author(s)
Abstract
Endothelial progenitor cells (EPCs) contribute to the recovery of neurological function after ischemic stroke. Indirect revascularization has exhibited promising effects in the treatment of cerebral ischemia related to moyamoya disease and intracranial atherosclerotic disease. The role of EPCs in augmenting the revascularization effect is not clear. In this study, we investigated the therapeutic effects of indirect revascularization combined with EPC transplantation in rats with chronic cerebral ischemia.
Subjects
Angiogenesis; Cerebral ischemia; Endothelial progenitor cells; Indirect revascularization; Microcirculation; Neuronal damage
SDGs
Publisher
BMC
Type
journal article