Polyoxygenated Steroids from the Gorgonian Isis hippuris
Resource
Journal of Natural Products 68 (6): 880-885
Journal
Journal of Natural Products
Journal Volume
68
Journal Issue
6
Pages
880-885
Date Issued
2005
Date
2005
Author(s)
Chao, Chih-Hua
Huang, Long-Fei
Yang, Yi-Lea
Su, Jui-Hsin
Wang, Guey-Horng
Chiang, Michael Y.
Wu, Yang-Chang
Sheu, Jyh-Horng
Abstract
Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14-19 have been found to exhibit significant cytotoxicity against several cancer cell lines. ? 2005 American Chemical Society and American Society of Pharmacognosy.
Other Subjects
3 acetyl 2 desacetylhippurin 1; hippuristanol derivative; natural product; unclassified drug; analytic method; article; cancer cell culture; chemical structure; coral; crystal structure; cytotoxicity; Isis hippuris; nonhuman; oxygenation; steroid analysis; structure analysis; X ray diffraction; Animals; Anthozoa; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Steroids; Tumor Cells, Cultured; Anthozoa; Gorgonia; Hippuris
Type
journal article
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