Response Inhibition Deficits of Executive Function and Suicidal Behavior in Schizophrenic Patients
Date Issued
2007
Date
2007
Author(s)
Su, Tsung-Wei
DOI
zh-TW
Abstract
Objective: Schizophrenic patients have working memory impairment. This study tested the impaired working memory may be associated with suicidal behavior in schizophrenic patients.
Method: The subjects were 30 schizophrenic persons with or without past suicidal behavior. All subjects were interviewed with Structured Clinical Interview for DSM-IV-TR Axis I disorders and evaluated with a sociodemographic and clinical questionnaire, the Positive and Negative Symptoms Scale (PANSS). They were also assessed with a battery of neuropsychological tests. General cognitive function was measured with Mini-Mental Status Examination (MMSE). Verbal working memory was measured with the WAIS digit span tests, spatial working memory was measured with WMS spatial span, and the Conners’ Continuous Performance Test, version II (CPT II) was used to test executive function.
Results: (1) In previous suicidal attempters group (N=11), there were higher CPT II commission error rate (49.7±21.1%) and lower detectability value (0.51±0.35) compared to the no suicidal history group. (N=19; 29.3±14.8%, p<0.01; 0.81±0.34; p<0.05) (2) The severity of psychopathological symptoms in PANSS rating showed significant correlation with MMSE scores, and omission error rates, response criterion in CPT II. (3) Spatial working memory showed significant correlation to omission error rates and hit reaction time in CPT II, while verbal working memory depend on education years
Conclusion: We postulated that response inhibition deficits of executive function in working memory were correlated to the past suicidal behaviors in schizophrenic patients. Regarding executive function of working memory, previous suicidal attempters had higher commission error rates, and the severity of psychopathology was correlated to higher omission error rates in CPT II results.
Subjects
自殺
精神分裂症
工作記憶
反應抑制
憂鬱症
suicide
schizophrenia
working memory
response inhibition
depressive disorder
SDGs
Type
text
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