More Evidence Supports the Association of Ppp3cc with Schizophrenia
Resource
MOLECULAR PSYCHIATRY v.12 n.10 pp.966-974
Journal
MOLECULAR PSYCHIATRY
Journal Volume
v.12
Journal Issue
n.10
Pages
966-974
Date Issued
2007
Date
2007
Author(s)
LIU, YU-LI
FANN, CATHY SHENG-JIUAN
LIU, CHIH-MIN
Abstract
Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits; a regulatory subunit of calcineurin B (CNB), and a catalytic subunit of calcineurin A (CNA). PPP3CC is the gamma isoform of CNA located at the chromosome 8p21.3 region. To evaluate the association between PPP3CC and schizophrenia in the Taiwanese population, ten SNP markers across the gene were genotyped by the method of MALDI-TOF in 218 schizophrenia families with at least two affected siblings. One SNP (rs 2272080) located around the exon 1 untranslated region was nominally associated with schizophrenia (p=0.024) and significantly associated with the expression of PPP3CC in lymphoblast cell line; the TT and TG genotype had significantly higher relative expression levels than the GG genotype ( p=0.0012 and p=0.015, respectively). In further endophenotype stratification, the single locus of rs2272080 and the haplotypes of both two-SNP haplotype (rs7833266-rs 2272080) and seven-SNP haplotype (rs 2461491- rs2469758- rs 2461489- rs2469770- rs2449340- rs1482337- rs2252471 ) showed significant associations with the subgroup of schizophrenia with deficits of the sustained attention as tested by the Continuous Performance Test (CPT, p<0.05) and the executive functioning as tested by the Wisconsin Card Sorting Test ( WCST, p<0.05). The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia.
Subjects
calcineurin
PPP3CC
calcineurin A gamma
8p21.3
SNP