Differential Releases of Dopamine and Neuropeptide Y from Histamine-Stimulated PC12 Cells Detected by an Aptamer-Modified Nanowire Transistor

Journal
Small
Journal Volume
12
Journal Issue
40
Pages
5524-5529
Date Issued
2016
Author(s)
S. Banerjee
Y. J. Hsieh
C. R. Liu
N. H. Yeh
H. H. Hung
Y. S. Lai
A. C. Chou
Y. T. Chen
DOI
URI
Abstract
Silicon nanowire field-effect transistors modified with specific aptamers can directly detect the minute dopamine and neuropeptide Y released from cells. The binding of these molecules to the aptamers results in a conductance change of the transistor biosensor and illustrates the differential releasing mechanisms of these molecules stored in various vesicle pools.
SDGs

[SDGs]SDG7

Type
journal article

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