Consensus Statement on Antimicrobial Therapy of Intra-Abdominal Infections in Asia
Resource
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS v.30 n.2 pp.129-133
Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Journal Volume
v.30
Journal Issue
n.2
Pages
129-133
Date Issued
2007
Date
2007
Author(s)
Hsueh, Po-Ren
Hawkey, Peter Michael
Abstract
The selection of antimicrobial agents in the 2006 Guidelines (consensus statement) on Empiric Therapy for Complicated Intra-Abdominal Infections ( IAIs) in Asia was based on resistance and epidemiological data from the Asian region. In these 2006 guidelines, single agent therapy using the beta-lactam/beta-lactamase inhibitors ampicillin/sulbactam or cefoperazone -sulbactam is recommended for mild-to- moderate cases, while piperacillin- tazobactam is recommended for high-severity cases. When using carbapenems, ertapenem is recommended for mild-to-moderate cases, while imipenem and meropenem are recommended for high-severity cases. For combination regimes , two types of agents are recommended: cephalosporin-based and monobactam- based. For mild-to- moderate cases, a third generation cephalosporin plus metronidazole is recommended. For high-severity cases, a third or fourth generation cephalosporin plus metronidazole+ /- amikacin is recommended. For the monobactam-based regimen , aztreonam plus metronidazole is recommended for high- severity cases only. (c) 2007 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
Subjects
intra-abdominal infections
antimicrobial therapy
Asia
consensus