Predictive factors in recurrent spontaneous aborters: A multicenter study
Resource
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY v.33 n.2 pp.165-170
Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Journal Volume
v.33
Journal Issue
n.2
Pages
165-170
Date Issued
1995
Date
1995
Author(s)
CAUCHI MAURICE N.
COULAM CAROLYN B.
COWCHOCK SUSAN
HO, HONG-NERNG
GATENBY PAUL
JOHNSON PETER M.
LUBS MARIE LOUISE E.
MCINTYRE JONE A.
RAMSDEN GORDON H.
SMITH J. BRUCE
SHARPE KEN
Abstract
Problem: Compare data from several centers relating to success rates in recurrent spontaneous miscarriage and assess the significance of indicators of subsequent pregnancy loss. Method: Data from 777 couples with unexplained recurrent spontaneous abortion from individual studies at seven centers were analyzed using logistic regression analysis. The following covariates: age of patient, number of previous spontaneous abortions, length of previous abortions history, sub- infertility index (defined as the product of the number of spontaneous abortions and the abortion history), whether a patient was a primary or secondary aborter, and whether a patient had received leukocyte immunotherapy. Results: There was a highly significant difference between the seven centers in success rates in the subseqhent pregnancy and a highly significant association between success rate and each of the following covariates: the number of previous spontaneous abortions, the length of the previous abortion history and sub- infertility index. In particular, for each increase of 10 units in the value of the sub- infertility index, up to a value of 30, the odds in favor of a successful pregnancy decreased by a factor of 0.6, i.e. , 40% . There was, however, little evidence of an association between the success rate in the subsequent pregnancy and age, parity, or immunization with cells from the husband. Conclusions: The sub-infertility index may be a useful measure of likelihood of success in a subsequent pregnancy. #1848#