Paraminabeolides A-F, cytotoxic and anti-inflammatory marine withanolides from the soft coral Paraminabea acronocephala
Journal
Journal of Natural Products
Journal Volume
74
Journal Issue
5
Pages
1132-1141
Date Issued
2011
Author(s)
Abstract
(Chemical Equation Presented) Six new withanolides, paraminabeolides A-F (1-6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7-11), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher's method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1-4 and 7-10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7-10 also could effectively reduce the expression of COX-2 protein. ? 2011 The American Chemical Society and American Society of Pharmacognosy.
Other Subjects
antiinflammatory agent; cyclooxygenase 2; cytotoxic agent; inducible nitric oxide synthase; minabeolide 1; minabeolide 2; minabeolide 4; minabeolide 5; minabeolide 8; paraminabeolide A; paraminabeolide B; paraminabeolide C; paraminabeolide D; paraminabeolide E; paraminabeolide F; unclassified drug; antiinflammatory activity; article; breast carcinoma; carbon nuclear magnetic resonance; cell strain HepG2; coral; cytotoxicity; drug isolation; drug structure; heteronuclear multiple bond correlation; human; human cell; infrared spectroscopy; lung carcinoma; macrophage; nonhuman; nuclear Overhauser effect; Paraminabea acronocephala; protein expression; proton nuclear magnetic resonance; Animals; Anthozoa; Anti-Inflammatory Agents; Antineoplastic Agents; Cyclooxygenase 2 Inhibitors; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Molecular Structure; Nitric Oxide Synthase Type II; Nuclear Magnetic Resonance, Biomolecular; Withanolides; Alcyonacea
Type
journal article