The Effects of Auditory Cueing on Rhythmic Movement and Cortical Excitability in Patients with Parkinson’s Disease
Date Issued
2014
Date
2014
Author(s)
Lam, In-Leng
Abstract
Background:
Parkinson’s disease (PD) is a progressive degenerative disease of central nervous systems deficit. The clinical symptoms of Parkinson’s disease include many motor tasks: difficult in initiating movement, performing rhythmic movement. Rehabilitation such as physical therapy, which aims to improve patient’s quality of life and functions, is a non-invasive treatment and value for PD patients. Auditory cueing is a technique that widely applied on training patients with Parkinson’s disease. Some studies revealed that auditory cues could improve motor performance. However, the mechanism under this treatment technique is still unknown.
Objective：
This study was to investigate the effect of auditory cueing on rhythmic finger movement in patients with Parkinson’s disease. Neurophysiological data such as motor cortex excitability and blood flow in prefrontal cortex were assessed by using transcranial magnetic stimulation (TMS) and near infrared spectroscopy (NIRS).
Methods: This study was a cross-over study. Patients diagnosed as Parkinson’s disease received two sessions of experiment in random order, one was external triggered (ET) group which received auditory cueing while performing movement, another group was self-initiated (SI) group which performing movement after listening to required movement rhythm and initiate the movement themselves.
Results:
Eighteen PD patients aged 60.3 ± 6.5 years participated in this study. The Hoehn and Yahr stage was I-III. The CV of fast tapping was significantly decreased in ET group (Z = -2.635, p = .008). The short intracortical inhibition (SICI) in 2 ms and 3 ms were significant larger (Z = -3.010, p = .003; Z = -2.045, p = .041, respectively) after tapping with concurrent external cues. For hemodynamics in prefrontal cortex, the concentration of Hb-Diff and tHb was significantly increased over time in both ET group and SI group.
Conclusions:
Concurrent auditory cueing had significant benefit in rhythmic movement and able to modulate the cortical excitability in the motor cortex.
Subjects
聽覺提示
巴金森氏症
節律性動作
經顱磁刺激
近紅外線吸收光譜儀
Type
thesis
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