Pioglitazone and bladder cancer: A population-based study of Taiwanese
Journal
Diabetes Care
Journal Volume
35
Journal Issue
2
Pages
278-280
Date Issued
2012
Author(s)
Abstract
OBJECTIVE - The association between pioglitazone and bladder cancer has not been investigated in Asians. We aimed to investigate this association. RESEARCH DESIGN AND METHODS - A total of 1,000,000 individuals were randomly sampled from the National Health Insurance database, and incident cases of bladder cancer during the period from 1 January 2006 to 31 December 2009 were analyzed among 54,928 patients with type 2 diabetes and without previous bladder cancer. RESULTS - Among 165 incident case subjects, 10 (0.39%) were ever users and 155 (0.30%) were never users of pioglitazone (adjusted hazard ratio in full model 1.305 [95% CI 0.661-2.576]). All bladder cancer in ever users occurred within a duration of therapy <24 months, suggesting an early effect of pioglitazone on bladder cancer or late use of pioglitazone in high-risk patients. CONCLUSIONS - The association between pioglitazone and bladder cancer was not significant. However, confirmation of this finding is required because of the possible lack of statistical power owing to the small number of events. ? 2012 by the American Diabetes Association.
SDGs
Other Subjects
pioglitazone; adult; article; bladder cancer; cancer incidence; controlled study; disease association; drug use; female; high risk patient; human; major clinical study; male; non insulin dependent diabetes mellitus; population research; Taiwan; Asian Continental Ancestry Group; Female; Humans; Hypoglycemic Agents; Male; Thiazolidinediones; Urinary Bladder Neoplasms
Type
journal article