Regulation of the expression of cytoplasmic polyadenylation element binding proteins for the treatment of cancer
Journal
Anticancer Research
Journal Volume
36
Journal Issue
11
Pages
5673-5680
Date Issued
2016
Author(s)
Abstract
Regulated mRNA translation plays an important role in normal cellular functions and cytoplasmic polyadenylation element binding proteins (CPEBs) are the key factors that control the elongation of poly(A) tail during translation. The expression of various CPEBs has been noted to be linked to tumorigenesis, tumor growth, invasiveness and angiogenesis; however, different CPEBs appear to play diverse roles in cancer. The evidence from the literature suggests that CPEB1 and CPEB3 act more likely as tumor suppressors; in contrast, CPEB2 and CPEB4 mainly exert oncogenic effects. In addition, different CPEB subtypes may interact with each other to regulate tumorigenesis. All four CPEB mRNAs contain multiple microRNA (miRNA) binding sites, while the functions of CPEBs are regulated by various miRNAs. These results indicate that CPEBs play a significant role in tumorigenesis; therefore, manipulation of the expression of different subtypes of CPEBs might modulate the behavior of cancer cells and provide new therapeutic concepts for cancer therapy. However, more studies are required to clarify their definite role in tumor development.
Subjects
Cancer; CPEB; MicroRNA; Review; Tumorigenesis
SDGs
Other Subjects
cytoplasmic polyadenylation element binding protein; cytoplasmic polyadenylation element binding protein 1; cytoplasmic polyadenylation element binding protein 2; cytoplasmic polyadenylation element binding protein 3; cytoplasmic polyadenylation element binding protein 4; messenger RNA; microRNA; unclassified drug; vasculotropin; transcription factor; angiogenesis; binding site; breast cancer; cancer cell; cancer therapy; carcinogenesis; colorectal cancer; disease course; gene expression regulation; glioma; human; myeloma; neoplasm; non small cell lung cancer; nonhuman; ovary cancer; pancreas cancer; priority journal; prostate cancer; protein expression; protein interaction; Review; RNA translation; stomach cancer; tumor growth; tumor invasion; uterine cervix cancer; cytoplasm; metabolism; Neoplasms; polyadenylation; Cytoplasm; Humans; Neoplasms; Polyadenylation; Transcription Factors
Publisher
International Institute of Anticancer Research
Type
Review