Role of gut microbiota in identification of novel TCM-derived active metabolites
Journal
Protein & cell
Date Issued
2020-09-15
Author(s)
Lin, Tzu-Lung
Lu, Chia-Chen
Lai, Wei-Fan
Wu, Ting-Shu
Lu, Jang-Jih
Chen, Young-Mao
Tzeng, Chi-Meng
Liu, Hong-Tao
Wei, Hong
Abstract
Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing to a lack of formal scientific validation, the absence of information regarding the mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by the host, but rather enter the intestine to be transformed by gut microbiota. The gut microbiota is a microbial community living in animal intestines, and functions to maintain host homeostasis and health. Increasing evidences indicate that TCM herbs closely affect gut microbiota composition, which is associated with the conversion of herbal components into active metabolites. These may significantly affect the therapeutic activity of TCMs. Microbiota analyses, in conjunction with modern multiomics platforms, can together identify novel functional metabolites and form the basis of future TCM research.
Subjects
Traditional Chinese Medicine; herbs; microbiota; multiomics; transformation
SDGs
Type
other