Association of TRAIL receptor with phosphatase SHP-1 enables repressing T cell receptor signaling and T cell activation through inactivating Lck
Journal
Journal of biomedical science
Journal Volume
31
Journal Issue
1
Pages
33
Date Issued
2024-03-27
Author(s)
Chyuan, I-Tsu
Liao, Hsiu-Jung
Tan, Tse-Hua
Chuang, Huai-Chia
Chu, Yu-Chuan
Pan, Meng-Hsun
Wu, Chien-Sheng
Abstract
T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that transduces apoptotic signals to induce cell death. Recent studies have indicated that TRAIL-R regulates T cell-mediated immune responses by directly inhibiting T cell activation without inducing apoptosis; however, the distinct signaling pathway that regulates T cell activation remains unclear. In this study, we screened for intracellular TRAIL-R-binding proteins within T cells to explore the novel signaling pathway transduced by TRAIL-R that directly inhibits T cell activation.
Subjects
Phosphatase; SHP-1; T cell receptor signaling; TRAIL receptor
SDGs
Type
journal article