Whole-body 18F-FDG PET in recurrent or metastatic nasopharyngeal carcinoma
Journal
Journal of Nuclear Medicine
Journal Volume
46
Journal Issue
5
Pages
770-774
Date Issued
2005
Author(s)
Abstract
The aim of this retrospective study was to evaluate the sensitivity and prognostic significance of whole-body 18F-FDG PET for nasopharyngeal carcinoma (NPC) patients for whom there was a suspicion of recurrence or metastasis by conventional radiologic or clinical findings during their follow-up examinations. Methods: Whole-body 18F-FDG PET examinations were performed on 64 Taiwanese NPC patients (14 female, 50 male; mean age ± SD, 45.8 ± 13.0 y; age range, 16-75 y) 4-70 mo (mean ± SD, 14.1 ± 13.5 mo) after radiotherapy or induction chemotherapy followed by concurrent chemoradiotherapy from February 1997 to May 2001. The accuracy of 18F-FDG PET detection for each patient was determined by the histopathologic results or other clinical evidence. Results: The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 18F-FDG PET images in the diagnosis of NPC recurrence or metastases and secondary primary cancers were 92%, 90%, 92%, 90%, and 91%, respectively. Furthermore, the presence of 18F-FDG hyper metabolism was highly correlated with the survival time of NPC patients. Conclusion: Whole-body 18F-FDG PET is a sensitive follow-up diagnostic tool for the evaluation of NPC recurrences and metastases. It is also an effective prognostic indicator for NPC patients. To determine the optimized utilization of 18F-FDG PET in the follow-up for NPC patients, further cost-effectiveness analysis of 18F-FDG PET in combination with conventional management is necessary.
SDGs
Other Subjects
fluorodeoxyglucose f 18; diagnostic agent; fluorodeoxyglucose f 18; radiopharmaceutical agent; accuracy; adolescent; adult; aged; article; cancer staging; chemotherapy; controlled study; female; follow up; human; hypermetabolism; major clinical study; male; nasopharynx carcinoma; positron emission tomography; priority journal; recurrent cancer; retrospective study; sensitivity and specificity; Taiwan; whole body scintiscanning; carcinoma; metastasis; methodology; middle aged; nasopharynx tumor; positron emission tomography; prognosis; reproducibility; risk assessment; risk factor; scintiscanning; treatment outcome; tumor recurrence; whole body counting; Adolescent; Adult; Aged; Carcinoma; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Reproducibility of Results; Retrospective Studies; Risk Assessment; Risk Factors; Sensitivity and Specificity; Treatment Outcome; Whole-Body Counting
Type
journal article