B型肝炎病毒基因型及表面抗原T細胞抗原決定部位基因變異慢性B型肝炎病毒感染病程的影響(1/3)
Date Issued
2002
Date
2002
Author(s)
張美惠
DOI
902314B002154
Abstract
Background/Aim: During the natural history of hepatitis B virus (HBV) infection, clinical course and outcome
differs in different individuals. The aim of this study is to investigate the effect of HBV genotypes on the clinical
course and hepatitis B e antigen/antibody seroconversion during chronic HBV infection. Subjects and Methods:
We longitudinally followed up 250 HBsAg carrier children and performed HBV genotype study in these
children (Group I, 67 children with persistently positive HBeAg; Group II, 148 children who have been
spontaneously seroconverted from HBeAg seropositive to anti-HBe positive during follow-up; Group III, 24
children who have been anti-HBe seropositive when they entered our long term follow-up study). Another 25
children (Group IV) with HBV-related hepatocellular carcinoma (HCC) were also recruited. The genotyping was
performed by polymerase chain reaction (PCR) using type-specific primers. Results: Genotype B was 71%, 73%,
and 92% in Group I, II, and III respectively. Genotype C was 25%, 7%, and 0% in Group I (p=0.01), II, and III
respectively. During long-term follow-up Genotype changing occurred in 10.8% of these 239 study subjects. For
the HCC group (group IV), Genotype B is still predominant (68%) than Genotype C (11%). Conclusion: HBV
Genotype B is the commonest one in children Taiwan. Genotype C might delay HBeAg seroconversion. The role
it played in the pathogenesis of chronic liver damage is worthy of further attention. Genotype changing seemed
not an uncommon event in the natural history of childhood HBV chronic infection. For childhood HCC,
Genotype B is the dominant one.
Subjects
hepatitis B virus
genotype
HBeAg seroconver sion
hepatoma
children
SDGs
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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