A multifunctional peptide for targeted imaging and chemotherapy for nasopharyngeal and breast cancers
Journal
Nanomedicine: Nanotechnology, Biology, and Medicine
Journal Volume
11
Journal Issue
6
Pages
1425-1434
Date Issued
2015
Author(s)
Abstract
The L-peptide plays a role as a universal ligand binding specifically to nasopharyngeal carcinoma (NPC) and other cancers but not normal cells. It was used to link iron oxide nanoparticles, and injected intravenously to SCID mice bearing NPC and breast cancer xenografts for MR analysis, and showed significant change of MR signal intensity in the xenograft regions. Using this conjugate as a ligand to localize the L-peptide targeted protein in the cancer surgical specimens, a clear reaction product was identified in the tumor cells of both cancer types. If the L-peptide-linked-liposomal doxorubicin was used to treat the SCID mice bearing other NPC or breast cancer xenograft, a high efficacy of chemotherapy with minimal adverse effect was observed. In conclusion, the L-peptide has a considerable potential for clinical usage for targeted imaging, peptide histochemical localization of targeted protein, and targeted chemotherapy for different cancer types. From the Clinical Editor: Targeted chemotherapy to cancer cells will enable maximum drug delivery but minimal systemic side effects. In this article, the authors identified a protein, L-peptide, on tumor cells. They also subsequently confirmed the specificity of this protein in animal experiments using iron oxide nanoparticles. The discovery of this marker could lead to future development of better chemotherapy. ? 2015 Elsevier Inc.
SDGs
Other Subjects
Biochemistry; Cells; Chemotherapy; Cytology; Diseases; Iron oxides; Ligands; Magnetic nanoparticles; Mammals; Medical imaging; Metal nanoparticles; Peptides; Tumors; Animal experiments; Breast Cancer; Breast cancer xenografts; Iron oxide nanoparticle; Liposomal doxorubicin; Nasopharyngeal carcinoma; Surgical specimens; Targeted chemotherapy; Targeted drug delivery; doxorubicin; iron oxide; l peptide; magnetic nanoparticle; nanoparticle; peptide; protein; unclassified drug; nanoparticle; peptide; adverse outcome; animal cell; animal experiment; animal model; Article; breast cancer; cancer chemotherapy; controlled study; drug efficacy; histochemistry; image analysis; ligand binding; liposomal delivery; mouse; nasopharynx cancer; nonhuman; nuclear magnetic resonance imaging; protein targeting; reaction analysis; SCID mouse; tumor xenograft; animal; Breast Neoplasms; drug screening; Nasopharyngeal Neoplasms; nuclear magnetic resonance imaging; tumor cell line; Animalia; Mus; Animals; Breast Neoplasms; Cell Line, Tumor; Magnetic Resonance Imaging; Mice; Mice, SCID; Nanoparticles; Nasopharyngeal Neoplasms; Peptides; Xenograft Model Antitumor Assays
Publisher
Elsevier Inc.
Type
journal article