Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis
Journal
Journal of Biological Chemistry
Journal Volume
288
Journal Issue
30
Pages
22174-22183
Date Issued
2013
Author(s)
Abstract
Background: How Fgfr1 mutations cause cleft palate is unclear. Results: Deleting Fgfr1 in neural crest cells caused defects in both palate shelf epithelium and mesenchyme and led to cleft palate. Conclusion: FGFR1 signaling in cranial neural crest (CNC) cells regulates palate shelf growth and fusion during palatogenesis. Significance: The finding for the first time demonstrates how FGF signaling in CNC cells regulates palatogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
SDGs
Type
journal article