Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands
Journal
Antimicrobial Agents and Chemotherapy
Journal Volume
57
Journal Issue
11
Pages
5239-5246
Date Issued
2013
Author(s)
Kim D.H.
Choi J.-Y.
Kim H.W.
Kim S.H.
Chung D.R.
Peck K.R.
Thamlikitkul V.
So T.M.-K.
Yasin R.M.D.
Carlos C.C.
Hsu L.Y.
Buntaran L.
Lalitha M.K.
Song J.-H.
Ko K.S.
Abstract
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaRtype resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenemresistant A. baumannii in Asia. Copyright © 2013, American Society for Microbiology. All Rights Reserved.
SDGs
Type
journal article