Synthesis and Research of argeted Magnetic Immune Hollow Drug Carrier

In our study, we synthesize the linear copolymer of MMA (methyl methacrylate) and MAA (methacrylic acid) which has carboxyl groups. Then we use Poly(MMA-MAA) as a seed, adding different amount of crosslinker and different ratio of NIPAAM (N-isopropylacrylamide)/MAA (methacrylic acid) to synthesize Poly(MMA-MAA)/(MAA-NIPAAM) copolymer. We use ammonium hydroxide to dissolve Poly(MMA-MAA) to get hollow Poly(NIPAAM-MAA) latex at different temperature and span. We use transmission electron microscopy、UV-vis SpectropHotometer to observe hollow Poly(MAA-NIPAAM) latex . Then synthesizing the magnetic hollow latex, we use different method synthesizing it from the traditional method. First, we synthesize the hollow latex. Second, using the functional group(-COOH) on the hollow latex surface to bond Fe2+ and Fe3+. Finally, we put ammonium hydroxide into the latex, and we can get magnetic hollow latex by im-situ method. Final step is to synthesize Poly(MAA-NIPAAM)/Fe3O4/A(MAA-NIPAAM) magnetic hollow latex . We adding different ratio of NIPAAM/MAA and different amount of initiator and crosslinker into Poly(MAA-NIPAAM)/Fe3O4 latex to synthesize Poly(MAA-NIPAAM)/Fe3O4/A(MAA-NIPAAM) magnetic hollow latex. Then we use transmission electron microscopy、UV-vis SpectropHotometer to observe property of Poly(MAA-NIPAAM)/Fe3O4/A(MAA-NIPAAM) magnetic hollow latex.