Anti-inflammatory cembranolides from the soft coral Lobophytum durum
Resource
Bioorganic & Medicinal Chemistry 17 (11): 3763-3769
Journal
Bioorganic and Medicinal Chemistry
Journal Volume
17
Journal Issue
11
Pages
3763-3769
Date Issued
2009
Author(s)
Abstract
Chemical investigation of the soft coral Lobophytum durum resulted in the isolation of seven new cembranolides, durumolides F-L (1-7), as well as one previously characterized cembranolides, sinularolide D (8). The molecular structures of these isolated metabolites were determined mainly through NMR techniques and HRESIMS analysis. Moreover, the absolute configurations of 1 and 5 were established by application of modified Mosher's method. The antibacterial activities, anti-inflammatory effects, and anti-HCMV (Human cytomegalovirus) endonuclease activity of metabolites 1-8 were also evaluated in vitro. Anti-inflammatory activity of metabolites 1 and 6 (10 μM) significantly reduced the levels of the iNOS protein to 0.8 ± 0.6% and 5.7 ± 2.2%, respectively, and COX-2 protein to 47.8 ± 9.0% and 71.6 ± 5.8%, respectively. Metabolites 1-8 (100 μg/disk) exhibited weak antibacterial activity against Salmonella enteritidis. © 2009 Elsevier Ltd. All rights reserved.
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journal article
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