Outbreak of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated With Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan
Resource
American Journal of Public Health 93 (3): 489-492
Journal
American Journal of Public Health
Pages
489-492
Date Issued
2003
Date
2003
Author(s)
Chen, Kow-Tong
Twu, Shiing-Jer
Chang, Hong-Jen
Lin, Ruey-Shiung
Abstract
Objectives. This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan. Methods. Forty-six SJS/TEN patients were matched to 92 controls according to month of arrival in Taiwan, sex, and age. Results. The odds ratio for development of SJS/TEN was 9.5 (95% confidence interval [Cl]=3.9, 23.9) among workers who had used both metronidazole and mebendazole sometime in the preceding 6 weeks. In addition, a gradient increase in the occurrence of SJS/TEN was found with an increasing level of exposure to metronidazole. Conclusions. This outbreak highlights the risk of SJS/TEN resulting from the use of both metronidazole and mebendazole and the need for control measures.
SDGs
Other Subjects
mebendazole; metronidazole; adult; amebiasis; article; dysentery; epidemic; ethnic group; female; human; major clinical study; male; prognosis; protozoal infection; race difference; risk factor; Stevens Johnson syndrome; Taiwan; toxic epidermal necrolysis
Type
journal article
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