Differential effects of the changes of LDL cholesterol and systolic blood pressure on the risk of carotid artery atherosclerosis
Journal
BMC Cardiovascular Disorders
Journal Volume
12
Pages
66
Date Issued
2012-08-17
Author(s)
Abstract
Background: The effects of baseline and changes in blood pressure and low density lipoprotein (LDL) cholesterol on the carotid intima media thickness (IMT) have not been well documented.Methods: A total of 2572 adults (mean age 53.8 years, 54.6% women) in a Taiwanese community undertook three blood pressure and LDL cholesterol examinations over 6 years. Latent growth curve modeling was used to investigate the effects of baseline and change in blood pressure and LDL cholesterol on IMT.Results: Greater baseline LDL and blood pressure were associated with an increase in IMT (0.005 ± 0.002 mm per 1 mg/dL [p = 0.006] and 0.041 ± 0.004 mm mmHg [p <0.0001], respectively. Change in blood pressure was associated with a significant increase in IMT (0.047±0.016, P = 0.004), whilst the association between change in LDL and change in IMT was not statistically significant (0.008±0.006, P = 0.20).Conclusions: Carotid IMT was associated with baseline blood pressure and LDL cholesterol, yet only changes of blood pressure, not LDL cholesterol, were related to carotid IMT during the 6-year observation. ? 2012 Chien et al.; licensee BioMed Central Ltd.
Subjects
Blood pressure; Carotid intima media thickness; Latent growth curve modeling; LDL cholesterol
SDGs
Other Subjects
glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; adult; arterial wall thickness; article; cardiovascular risk; carotid atherosclerosis; diagnostic imaging; ethnic group; female; glucose blood level; growth curve; human; major clinical study; male; prevalence; priority journal; systolic blood pressure; Taiwanese; Adult; Aged; Biological Markers; Blood Pressure; Carotid Artery Diseases; Carotid Intima-Media Thickness; Cholesterol, LDL; Cohort Studies; Female; Humans; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Taiwan; Time Factors
Type
journal article