A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region
Resource
Immunogenetics 46 (5): 376-382
Journal
Immunogenetics
Journal Volume
46
Journal Issue
5
Pages
376-382
Date Issued
1997
Date
1997
Author(s)
Abstract
A cosmid clone containing the chicken T-cell receptor alpha chain constant region (TCRAC) was sequenced. The cosmid contains the TCRAC gene, six putative joining gene segments (TCRAJ), and surprisingly, a chicken homologue for the human apoptotic suppressor gene, defender against cell death (DAD1). The DAD1 gene is 6.3 kilobases downstream of the TCRAC gene and has an inverted transcription orientation with respect to the TCRAC gene. The cDNA for the chicken DAD1 gene is 597 base pairs in length and encodes a highly conserved hydrophobic protein. The proximal location of DAD1 to the TCRAC locus has also been confirmed in both humans and mouse. The location of the DAD1 gene suggests that DAD1 may play an important role in T-cell related apoptotic activities.
SDGs
File(s)![Thumbnail Image]()
Loading...
Name
02.pdf
Size
351.23 KB
Format
Adobe PDF
Checksum
(MD5):46c57d5f9d6ad82e1f359b9e925e9d83