Bioactive Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum
Journal
Bulletin of the Chemical Society of Japan
Journal Volume
84
Journal Issue
10
Pages
1102-1106
Date Issued
2011
Author(s)
Abstract
Two new metabolites, crassumolides H and I (2 and 3), and crassumolide G (1) which was discovered for the first time from natural sources, were isolated from the ethyl acetate extract of a Taiwanese soft coral Lobophytum crassum, along with three known metabolites 46. The structures of metabolites 13 were elucidated by extensive spectroscopic analysis and comparison of the NMR data with those of known compounds. Compounds 13 were found to inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins at 10 μM in LPS-stimulated RAW264.7 marcophage cells. © 2011 The Chemical Society of Japan.
SDGs
Type
journal article