Study of Functional Circulatory Parameters Using Laser Doppler Flowmeter
Date Issued
2004
Date
2004
Author(s)
Hu, Chang-Lin
DOI
zh-TW
Abstract
Since 1973, the development of laser Doppler flowmetry has been widely used to measure the motion of particles. Among various applications, its biomedical application is especially noticeable. Characterizing for its noninvasive measurement, perfect resolution of velocity, and high spatial resolution, laser Doppler flowmetry has become an essential tool for clinical microcirculation researches.
We can’t directly judge whether circulatory function is dysfunctional through microcirculatory flow because the differences between the microcirculatory structures are massive and microcirculatory flow can easily change with external environment and internal causes such as temperature, probe pressure, pulsation, and respiration. However, the relative variation of the microcirculatory flow, for example, after mechanical or heat stimulus, can provide a lot of meaningfully physiological parameters. Thus in the research, we fasten our arms with the occlusion cuff, observing the relative variation of the microcirculatory flow in the fingertip through the variation of the automatic manometer. Then we can acquire functional circulatory parameters such as BZ, PF, and tp.
The research is mainly divided into two parts. The first part is the setup of the laser Doppler flow meter. We expect it to exactly reflect the variation of the microcirculatory flow. At present, the correlation coefficient R between the indexes of the flow meter's velocity <ω> and practically velocity of blood mimicking fluids has reached a high linear relation of 0.99. In the second part, we measure blood pressure and acquire functional circulatory parameters by using flowmeter. At present, the blood pressure measurement using our homemade laser Doppler flowmeter yielded the same accuracy as the one of auscultation sphygmomanometer (oscillometric method). Moreover, we can acquire functional circulatory parameters and judge whether we have a symptom of edema or peripheral arterial occlusive diseases.
We can’t directly judge whether circulatory function is dysfunctional through microcirculatory flow because the differences between the microcirculatory structures are massive and microcirculatory flow can easily change with external environment and internal causes such as temperature, probe pressure, pulsation, and respiration. However, the relative variation of the microcirculatory flow, for example, after mechanical or heat stimulus, can provide a lot of meaningfully physiological parameters. Thus in the research, we fasten our arms with the occlusion cuff, observing the relative variation of the microcirculatory flow in the fingertip through the variation of the automatic manometer. Then we can acquire functional circulatory parameters such as BZ, PF, and tp.
The research is mainly divided into two parts. The first part is the setup of the laser Doppler flow meter. We expect it to exactly reflect the variation of the microcirculatory flow. At present, the correlation coefficient R between the indexes of the flow meter's velocity <ω> and practically velocity of blood mimicking fluids has reached a high linear relation of 0.99. In the second part, we measure blood pressure and acquire functional circulatory parameters by using flowmeter. At present, the blood pressure measurement using our homemade laser Doppler flowmeter yielded the same accuracy as the one of auscultation sphygmomanometer (oscillometric method). Moreover, we can acquire functional circulatory parameters and judge whether we have a symptom of edema or peripheral arterial occlusive diseases.
Subjects
雷射都卜勒
水腫
循環功能參數
血壓
周邊動脈阻塞性疾病
laser Doppler
functional circulatory parameters
blood pressure
edema
PAOD
Type
thesis
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