Fast CEC-MS using poly(dimethylsiloxane) microinjector, short packed column, and low-sheath-flow interface
Resource
JOURNAL OF SEPARATION SCIENCE, 34(18), 2538-2543
Journal
Journal of Separation Science
Pages
2538-2543
Date Issued
2011
Date
2011
Author(s)
Chen, Chao-Jung
Wang, Che-Wei
Her, Guor-Rong
Abstract
A fast CEC-MS approach based on a microinjector and a short CEC column was developed. Poly(dimethylsiloxane) was used as the substrate for microinjector fabrication. A short capillary column (∼5 cm) packed with 5 μm octadecyl silica particles was inserted into the microinjector. The microinjector CEC device was interfaced to ESI-MS using a low-flow sheath liquid interface. The device delivers the advantages of sample introduction, pre-concentration, elution, and fast analysis as in chip-CEC yet avoids the difficulty of packing stationary material into the chip. The online pre-concentration and CEC-MS analysis capabilities of this device were demonstrated by analysis of a six-triazine mixture. A signal enhancement of 20-99-fold was achieved with a sample loading time of 180 s.
Type
journal article
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