Fabrication of a novel porous PGA-chitosan hybrid matrix for tissue engineering
Resource
Biomaterials 24(2003), 1047–1057
Journal
Biomaterials
Pages
-
Date Issued
2003
Date
2003
Author(s)
DOI
246246/2006111501243789
Abstract
Polyglycolide (PGA) and chitosan mixture solution was prepared using solvents of low toxicity to create novel, porous,
biocompatible, degradable, and modifiable hybrid matrices for biomedical applications. The porosity of these PGA-chitosan hybrid
matrices (P/C matrices) was created by a thermally induced phase separation method. Two types of the P/C hybrid matrices
containing 70wt% PGA (P/C-1 matrix) and 30wt% PGA (P/C-2 matrix) were fabricated. Chitosan matrix was also prepared for
comparison. A 35-day in vitro degradation revealed that the weight losses for the P/C-1 and P/C-2 matrices were similar (B61%),
but the releases of glycolic acid from the P/C-1 and P/C-2 matrices were 95% and 60%, respectively. The P/C-1 matrix had higher
porosity and higher mechanical strength than the P/C-2 and chitosan matrices. Fibroblast cells cultivated in these matrices
proliferated well and the cell density was the highest in the P/C-1 matrix, followed by the chitosan and P/C-2 matrices, suggesting
good biocompatibility for the P/C-1 matrix. We thereby concluded that the P/C-1 matrix, due to its high strength, porosity,
biocompatibility and degradability, is a promising biomaterial. The presence of chitosan in the P/C matrices provides many amino
groups for further modifications such as biomolecule conjugation and thus enhances the application potential of the P/C hybrid
matrices in tissue engineering.
Subjects
Chitosan
Polyglycolide
Porous matrix
Tissue engineering
Publisher
Taipei:National Taiwan University Dept Chem Engn
Type
journal article
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