Carbapenem susceptibility among Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae isolates obtained from patients in intensive care units in Taiwan in 2005, 2007, and 2009
Journal
Diagnostic Microbiology and Infectious Disease
Journal Volume
81
Journal Issue
4
Pages
290-295
Date Issued
2015
Author(s)
Jean S.-S.
Lee W.-S.
Bai K.-J.
Yu K.-W.
Hsu C.-W.
Liao C.-H.
Chang F.-Y.
Ko W.-C.
Wu J.-J.
Chen Y.-H.
Chen Y.-S.
Liu J.-W.
Lu M.-C.
Liu C.-Y.
Chen R.-J.
Abstract
To investigate the evolutionary trends in non-susceptibility of carbapenems against the isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan during 2005-2009, we applied the breakpoints of MICs recommended by Clinical and Laboratory Standards Institute and European Committee on Antimicrobial Susceptibility Testing in 2013. Escalations in imipenem MIC levels for overall E. coli and E. cloacae isolates and extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae isolates were noted during this period. The overall MIC levels against imipenem and meropenem for subgroups of ESBL producers of 3 Enterobacteriaceae species were significantly higher than those of respective overall groups in 2007 and 2009. Compared with meropenem, we found that significant evidence of imipenem MIC creep and evidence of extraordinarily high rates of non-susceptibility to ertapenem among isolates of 3 species in 2009 existed. The prominent rises in rates of ertapenem non-susceptibility for ESBL-producing E. coli and K. pneumoniae during 2005-2009 and rate of ESBL positivity for E. cloacae between 4. years were notably found. Based on our findings, ertapenem should be used cautiously in management of the ICU infections caused by these potentially ESBL-producing Enterobacteriaceae isolates in Taiwan. ? 2015 Elsevier Inc.
SDGs
Other Subjects
carbapenem; ertapenem; extended spectrum beta lactamase; imipenem; meropenem; antiinfective agent; beta lactam; carbapenem derivative; imipenem; thienamycin derivative; antibiotic resistance; antibiotic sensitivity; Article; bacterium detection; bacterium identification; bacterium isolate; broth dilution; controlled study; disease surveillance; Enterobacter cloacae; Escherichia coli; extended spectrum beta lactamase producing Escherichia coli; extended spectrum beta lactamase producing Klebsiella pneumoniae; human; in vitro study; intensive care unit; Klebsiella pneumoniae; minimum inhibitory concentration; nonhuman; nonparametric test; prevalence; priority journal; Taiwan; trend study; drug effects; Enterobacter cloacae; Enterobacteriaceae; Enterobacteriaceae infection; Escherichia coli; isolation and purification; Klebsiella pneumoniae; microbial sensitivity test; microbiology; teaching hospital; Anti-Bacterial Agents; beta-Lactams; Carbapenems; Enterobacter cloacae; Enterobacteriaceae; Enterobacteriaceae Infections; Escherichia coli; Hospitals, Teaching; Humans; Imipenem; Intensive Care Units; Klebsiella pneumoniae; Microbial Sensitivity Tests; Taiwan; Thienamycins
Type
journal article