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  4. The application of ultrasound in detecting lymph nodal recurrence in the treated neck of head and neck cancer patients
 
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The application of ultrasound in detecting lymph nodal recurrence in the treated neck of head and neck cancer patients

Journal
Scientific Reports
Journal Volume
7
Journal Issue
1
Date Issued
2017
Author(s)
CHI-MAW LIN  
CHENG-PING WANG  
Chun-Nan Chen  
CHE-YI LIN  
Li T.-Y.
Chou C.-H.
Hsu Y.-C.
Kuo P.-Y.
TSUNG-LIN YANG  
PEI-JEN LOU  
JENG-YUH KO  
TSENG-CHENG CHEN  orcid-logo
DOI
10.1038/s41598-017-04039-3
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021241985&doi=10.1038%2fs41598-017-04039-3&partnerID=40&md5=5908bf64b91202ba65fcdaa18f31139f
https://scholars.lib.ntu.edu.tw/handle/123456789/474418
Abstract
Early detection of neck lymph node (LN) recurrence is paramount in improving the prognosis of treated head and neck cancer patients. Ultrasound (US) with US-guided fine needle aspiration (FNA) and core needle biopsy (CNB) have been shown to have great accuracy for LN diagnoses in the untreated neck. However, in the treated neck with fibrosis, their roles are not clarified. Here, we retrospectively review 153 treated head and neck cancer patients who had received US and US-guided FNA/CNB. In multivariate logistic regression analyses, size (short-axis diameter >0.8 cm) (odds ratio (OR) 4.19, P = 0.007), round shape (short/long axis ratio >0.5) (OR 3.44, P = 0.03), heterogeneous internal echo (OR 3.92, P = 0.009) and irregular margin (OR 7.32, P < 0.001) are effective US features in predicting recurrent LNs in the treated neck. However, hypoechogenicity (OR 2.38, P = 0.289) and chaotic/absent vascular pattern (OR 3.04, P = 0.33) are ineffective. US-guided FNA (sensitivity/specificity: 95.24%/97.92%) is effective in the treated neck, though with high non-diagnostic rate (29.69%). US-guided CNB (sensitivity/specificity: 84.62%/100%) is also effective, though with low negative predictive value (62.5%). Overall, US with US-guided FNA/CNB are still effective diagnostic tools for neck nodal recurrence surveillance. ? 2017 The Author(s).
SDGs

[SDGs]SDG3

Other Subjects
adult; aged; diagnostic imaging; echography; female; fine needle aspiration biopsy; head and neck tumor; human; image guided biopsy; large core needle biopsy; lymph node; male; middle aged; pathology; procedures; retrospective study; sensitivity and specificity; tumor recurrence; young adult; Adult; Aged; Biopsy, Fine-Needle; Biopsy, Large-Core Needle; Female; Head and Neck Neoplasms; Humans; Image-Guided Biopsy; Lymph Nodes; Male; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Sensitivity and Specificity; Ultrasonography; Young Adult
Publisher
Nature Publishing Group
Type
journal article

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