Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene
Journal
Journal of agricultural and food chemistry
Journal Volume
68
Journal Issue
46
Pages
12788-12799
Date Issued
2020
Author(s)
Abstract
Supplementation with natural compounds found in fruits and vegetables has long been associated with a reduced risk of several types of cancer. Pterostilbene is a natural stilbenoid and a dimethylated analogue of resveratrol which is found primarily in blueberries. Pterostilbene exhibits a range of pharmacological properties, particularly anti-inflammatory and anticancer effects. Due to two methoxy groups in its skeleton, pterostilbene is more lipophilic than resveratrol and thus possesses higher intestinal permeability and cellular uptake and enhanced stability. Moreover, pterostilbene exhibits less toxicity and fewer adverse effects, providing it with superior potential in cancer chemoprevention and chemotherapy applications. Numerous research studies have demonstrated that pterostilbene possesses detoxification activities, mediating the anti-inflammation response, regulating the cell cycle, augmenting apoptosis, enhancing autophagy, and inhibiting tumor angiogenesis, invasion, and metastasis by modulating signal transduction pathways which block multiple stages of carcinogenesis. In this review, we illustrate that pterostilbene is a natural compound having bioavailability. The extensive metabolism of pterostilbene will be discussed. We also summarize recent research on pterostilbene's anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management. ? 2020 American Chemical Society.
Subjects
anti-inflammation; anticancer; bioavailability; chemoprevention; pterostilbene
SDGs
Other Subjects
Biochemistry; Cell death; Chemotherapy; Detoxification; Diseases; Resveratrol; Signal transduction; Anti-inflammatories; Anticancer properties; Cancer chemoprevention; Fruits and vegetables; Intestinal permeabilities; Molecular mechanism; Multistage carcinogenesis; Pharmacological properties; Pathology; antiinflammatory agent; antineoplastic agent; plant extract; pterostilbene; stilbene derivative; animal; bioavailability; cell proliferation; chemistry; drug effect; human; tumor cell line; Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Biological Availability; Cell Line, Tumor; Cell Proliferation; Humans; Plant Extracts; Stilbenes
Type
journal article