Identification of humoral antigenic determinants in the hepatitis C virus NS3 protein
Journal
Journal of Infectious Diseases
Journal Volume
174
Journal Issue
1
Pages
173-176
Date Issued
1996
Author(s)
Hwang L.-H.
Lai M.-Y.
Lee S.-Y.
Chian H.-M.
Chi W.-K.
Chu Y.-D.
Abstract
Immunoblot analysis on serum samples from 90 patients with chronic hepatitis C virus infection revealed four putative immunogenic regions within the NS3 protein of the virus: E (around aa 1250/1251), A (within aa 1250- 1334), A/B (around aa 1323 and 1334), and B/C (around aa 1407 and 1412). Among them, region E was most immunodominant, and region A was recognized much less frequently by patients with cirrhosis than by those with chronic hepatitis (10% vs. 46%, χ2 = 12.05. P < .01). The results suggest that region A might be a potential prognostic marker to differentiate chronic hepatitis from cirrhosis.
SDGs
Other Subjects
virus antigen; virus protein; adult; antigen recognition; article; controlled study; hepatitis C; Hepatitis C virus; human; humoral immunity; immunoblotting; liver cirrhosis; major clinical study; priority journal; prognosis
Publisher
Oxford University Press
Type
journal article