Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis
Journal
Journal of Oral Pathology and Medicine
Journal Volume
44
Journal Issue
4
Pages
300-305
Date Issued
2015
Author(s)
Abstract
Background: A portion of patients with recurrent aphthous stomatitis (RAS) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high blood homocysteine level with RAS. Methods: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 273 RAS patients were measured and compared with the corresponding levels in 273 age- and sex-matched healthy control subjects. Results: We found that 57 (20.9%), 55 (20.1%), 13 (4.8%), and 7 (2.6%) RAS patients had deficiencies of hemoglobin (Men < 13 g/dl, Women < 12 g/dl), iron (<60 μg/dl), vitamin B12 (<200 pg/ml), and folic acid (<4 ng/ml), respectively. Moreover, 21 (7.7%) RAS patients had abnormally high blood homocysteine level. RAS patients had a significantly higher frequency of hemoglobin, iron, vitamin B12, or folic acid deficiency and of abnormally elevated blood homocysteine level than healthy control subjects (all P-values = 0.000 except for folic acid P = 0.022). If 273 RAS patients were further divided into 32 patients with major-typed RAS (MjRAS) and 241 patients with minor-typed RAS (MiRAS), we found that male MjRAS patients had a significantly lower mean hemoglobin concentration than MiRAS patients (P = 0.021), but MjRAS patients had a significantly higher mean homocysteine level than MiRAS patients (P = 0.000). Conclusion: We conclude that there is a significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and abnormally high blood homocysteine level with RAS. ? 2014 John Wiley & Sons A/S.
Other Subjects
cyanocobalamin; folic acid; hemoglobin; homocysteine; iron; hemoglobin; homocysteine; adult; aged; aphthous stomatitis; Article; clinical assessment; controlled study; correlation analysis; female; folic acid blood level; hemoglobin blood level; human; iron blood level; major clinical study; male; nutritional deficiency; priority journal; statistical analysis; vitamin blood level; adolescent; aphthous stomatitis; blood; chi square distribution; cyanocobalamin deficiency; deficiency; folic acid deficiency; iron deficiency anemia; middle aged; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Chi-Square Distribution; Female; Folic Acid Deficiency; Hemoglobins; Homocysteine; Humans; Male; Middle Aged; Stomatitis, Aphthous; Vitamin B 12 Deficiency; Young Adult
Publisher
Blackwell Publishing Ltd
Type
journal article