Reactions of β-nitrostyrenes with Gragnard reagents
Journal
Tetrahedron Letters
Journal Volume
37
Journal Issue
35
Pages
6339-6342
Date Issued
1996
Date
1996
Author(s)
Abstract
α-Phenyl-β-nitrostyrene 1a and β-nitrostyrene 1b react with Grignard reagents to generate hydroxyimoyl halides 3 or nitrile oxides 4 after workup with ice cold concentrated aqueous HX acid solution. Carboxylic acids 5 are the only products isolated from 1b and products 3 or 4 are still obtained from 1a when concentrated sulfuric acid solution is used.
Other Subjects
carboxylic acid derivative; article; drug synthesis; reaction analysis; technique
Type
journal article
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