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  3. Clinical Laboratory Sciences and Medical Biotechnology / 醫學檢驗暨生物技術學系所
  4. Viral load and clinical features in children infected with seasonal influenza B in 2006/2007
 
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Viral load and clinical features in children infected with seasonal influenza B in 2006/2007

Journal
Journal of the Formosan Medical Association
Journal Volume
111
Journal Issue
2
Pages
83-87
Date Issued
2012
Author(s)
Tsou T.-P.
PEI-LAN SHAO  
CHUN-YI LU  
LUAN-YIN CHANG  
CHUAN-LIANG KAO  
PING-ING LEE  
PAN-CHYR YANG  
Lee C.-Y.
LI-MIN HUANG  
DOI
10.1016/j.jfma.2010.10.001
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/508003
Abstract
Background/Purpose: In influenza B infection, viral load is believed to be related to the severity of clinical illness. The correlation between viral load and symptoms is not known. We conducted a study to assess the relationship between virus load and clinical features in children infected with influenza B, in the hope that clinical features could be used as surrogate markers of viral load to guide treatment. Methods: Between December 2006 and February 2007, 228 patients with fever and respiratory symptoms were prospectively enrolled in our tertiary hospital-based study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was performed to determine viral load. Results: Real-time RT-PCR was positive for influenza B in 76 patients. Using virus culture as the gold standard, the sensitivity and specificity were 95% and 87%, respectively. Influenza culture positive rate significantly correlated with viral load (p = 0.03). The median copy number of influenza B virus in the 76 RT-PCR positive patients was 9735 copies/ml (range 4.8×10 1-2.0×10 6 copies/ml). Samples obtained later in the clinical course tended to have lower viral load (p = 0.7), while patient age (p = 0.72) and fever duration (p = 0.96) positively related to viral load. In patients >3 years of age, myalgia was related to statistically lower viral loads (14300 vs. 1180; p = 0.025). Patients with chills tended to have higher viral loads (72450 vs. 7640; p = 0.1). Patients with abdominal pain tended to have lower viral loads (1998 vs. 12550; p = 0.06). Conclusion: Culture rate positively correlated with viral load. Patients with myalgia had a lower viral load. ? 2012.
SDGs

[SDGs]SDG3

Other Subjects
influenza vaccine; oseltamivir; abdominal pain; acute otitis media; adolescent; age; article; child; clinical feature; disease course; disease duration; empyema; female; fever; gene dosage; human; infant; influenza; influenza B; influenza vaccination; major clinical study; male; myalgia; nonhuman; pneumonia; preschool child; prospective study; real time polymerase chain reaction; reverse transcription polymerase chain reaction; school child; seasonal influenza; seasonal influenza B; sensitivity and specificity; sinusitis; video assisted thoracoscopic surgery; virus culture; virus load; Abdominal Pain; Adolescent; Age Factors; Antiviral Agents; Child; Child, Preschool; Chills; Female; Fever; Humans; Infant; Influenza B virus; Influenza, Human; Male; Musculoskeletal Pain; Oseltamivir; Prospective Studies; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Viral Load
Type
journal article

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