Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on asian diagnostic criteria
Journal
Pancreas
Journal Volume
40
Journal Issue
2
Pages
200-205
Date Issued
2011
Author(s)
Kamisawa T.
Kim M.-H.
Liu Q.
Balakrishnan V.
Okazaki K.
Shimosegawa T.
Chung J.B.
Lee K.T.
TSUNG-CHUN LEE
Choudhuri G.
Abstract
OBJECTIVES: To clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) in Asia. METHODS: A retrospective, actual situation survey of AIP diagnosed by Asian criteria was conducted in 10 centers of Japan, Korea, Taiwan, China, and India. RESULTS: A total of 327 AIP cases (258 male and 69 female subjects; average age, 60.0 years) were enrolled. Obstructive jaundice was the most frequent initial symptom (46%-74%), followed by weight loss (4%-51%) and abdominal pain (19%-44%). Diffuse swelling of the pancreas was frequent in Japan (64%) and Korea (81%), but segmental swelling of the pancreas was more frequent in Taiwan (70%) and China (72%) (P < 0.01). Serum immunoglobulin G4 levels were elevated in 58%-100% of cases in Japan, Korea, and Taiwan. Pathologically, almost all AIPs in Asia were lymphoplasmacytic sclerosing pancreatitis. Sclerosing cholangitis was the most frequent extrapancreatic lesion (60%-81%). Steroid therapy was a major and effective therapeutic strategy in Japan, Korea, and Taiwan. However, the rate of resection or bypass operation was higher in Taiwan (40%) and China (72%) (P < 0.01). CONCLUSIONS: Features of AIP are fundamentally similar in Japan, Korea, Taiwan, and China. Knowledge of emerging AIP should be more widespread in Asia to avoid unnecessary operation. ? 2011 Lippincott Williams & Wilkins, Inc.
SDGs
Other Subjects
antinuclear antibody; immunoglobulin G4; prednisolone; rheumatoid factor; abdominal pain; abdominal swelling; adult; aged; antibody detection; article; Asian; autoimmune pancreatitis; China; chronic diarrhea; clinical assessment; clinical feature; comorbidity; computer assisted tomography; controlled study; diabetes mellitus; disease exacerbation; dyspepsia; fatigue; female; health survey; histopathology; human; immunoglobulin blood level; immunopathogenesis; India; Japan; Korea; major clinical study; male; nausea; obstructive jaundice; pancreas resection; pathophysiology; priority journal; prognosis; retrospective study; salivary gland swelling; sclerosing cholangitis; sex ratio; steroid therapy; swelling; symptom; Taiwan; weight reduction; Asia; Asian Continental Ancestry Group; Autoantibodies; Autoimmune Diseases; Biological Markers; Biopsy; Female; Health Status Indicators; Humans; Immunoglobulin G; Male; Middle Aged; Pancreatectomy; Pancreatitis; Predictive Value of Tests; Retrospective Studies; Steroids; Tomography, X-Ray Computed; Treatment Outcome
Type
journal article