The Effect of Intrathoracic Lesion Location on Initial Tyrosine Kinase Inhibitor Response in Advanced Oncogene-Addicted Non-Small Cell Lung Cancer: A Comparison Between RECIST 1.1 and a Novel Method of Response Assessment (MAX)
Journal
Clinical lung cancer
Date Issued
2022-08-07
Author(s)
Bang, Tami J
Hu, Junxiao
Patil, Tejas
Barón, Anna E
Gao, Dexiang
Sachs, Peter B
Camidge, D Ross
Abstract
Different subtypes of non-small cell lung cancer (NSCLC) are associated with different patterns of metastatic spread. Anatomic location of lesions in the chest may influence patterns of cancer growth and the shrinkage to therapy. Consequently, lesion location could affect apparent response rates per RECIST. We sought to explore this and develop, as needed, treatment response assessments less affected by the location.
Subjects
Lymph node; Parenchymal lung; Pleura; Targeted therapy
SDGs
Type
journal article